BioShake Q1

Professional heater-cooler shaker for 48/96/384 well microplates

Order nr. 2016-0600

  • BioShake Q1 | Professional heater-cooler shaker for microplates
  • BioShake Q1
  • BioShake Q1 | Professional heater-cooler shaker for microplates
  • BioShake Q1 | Professional heater-cooler shaker for microplates
  • BioShake Q1 | Professional heater-cooler shaker for microplates
  • BioShake Q1 | Professional heater-cooler shaker for microplates

Aluminium-10°C - 99°C2 mm orbit3000 rpmAdapterDeep Well96/384 Well

Key Benefits

The BioShake Q1 is the ideal and the most effective thermoshaker for 48/96/384 well microplates. The optimized orbital mixing system & mass balance elements reduce noise and vibrations significantly during cooling, heating and mixing of full loaded plates.

Fully adjustable between -20°C and 99.9°C and well beyond the cooling & heating accuracies of most other brands, Q1 guarantees excellent temperature control for every application.

The patented locking mechanism ELM locks the microplates quickly and safely, even at the highest mixing frequencies. Fast mixing processes with frequent plate changes can be performed in the routine as easy and safe.

 The Q1 module is only slightly larger than a standard microplate. 

All parts are inside the unit, no external components are necessary, only a PC is needed for controlling.

Small. Light. Efficient. Quiet.
  • Cooling & Heating & Mixing in one unit
  • Fast mixing from 200 up to 3,000 rpm
  • Fully adjustable between -20° to 99.9°C
  • Temperature range 24 K below RT, max: 99.9 °C
  • Cooling/Heating speed 12 K/min above RT
  • Wide range of perfected thermo adapters
  • Plate locking ELM ± 0.1 mm
  • Sensored zero-position ± 0.1 mm
  • Stylish aluminium housing
  • Reliable Peltier technology without coolant
  • No further external electronics 
  • Easy installation & simple start-up
  • Maintenance-free for many years
  • 2 years full warranty



Save time.

By combining the mixing operation with the incubation phase, reaction process times and operator workload are reduced and efficiency of many procedures is increased, resulting in a higher throughput.

The first-class finished aluminium housing gives the BioShake Q1 its essential functionality. It provides a high amount of security, device stability and ensures a long service life.


By planar orbital motion

German designed and manufactured, BioShake Q1 thermoshaker offer an ultra-efficient, 2-dimensional shaking axis so that samples mix completely in a fraction of the time of competing systems. The mixing orbit of 2.0 mm is always constant. The orbital shaking is precisely controlled, in fact, that you need never spin down your plates after mixing. 

Fully adjustable between 200 and 3,000 rpm, well beyond the speeds of most other brands, guarantees fast, splatter-free, mixing for tubes, glass vials or across an entire 96-well microplate.


Using of powerful peltier element technology

Many lab experiments require fast heating and cooling steps in a very accurate manner in range of -20°C up to 99°C. Precise temperature control is achieved for the Q1 by using optimally balanced cooling and heating elements. The novel peltier technology in combination with minimized electronics and reliable algorithms ensure a long useful life in each lab automation project.

BioShake Q1 is the ideal device to accurately set and maintain temperatures. The module is only slightly larger than a standard microplate. Fully adjustable between -20°C and 99°C and well beyond the cooling & heating accuracies of most other brands, Q1 guarantees excellent temperature control for microplates, tubes and vials.

All parts indside, only a PC is needed for controlling.

Temperatures are selectable from -20°C to 99°C in steps of 0.1°C. The nominal regulation accuracy is better than ±0.2°C with a uniformity of temperature distribution better than ±1.0°C at 4°C across the cooling surface.

Exchangeable thermo adapter plates and thermal blocks enable a perfect adaptation to microplates, tubes or glass vials.


Suitable for all microplates

Many robotic applications require precise dimensional spacing of pipet tips and robotic grippers relative to a microplate. The Edge Locking Mechanism (ELM) is the complete answer for repeatable and accurate positioning of microplates on a robotic deck. It consists of 2x2 stainless steel pins and a 2-point electromechanical mechanism to lock down microplates safely in the center of the module.

This patented locking mechanism locks the microplates quickly and safely, even at the highest mixing frequencies. Fast mixing processes with frequent plate changes can be performed in the routine as easy and safe.

For gripping of microplates the ELM opens the clamping automatically. This “universal” design is perfect for all types of platesin SBS format 127.7 x 85.5 mm: from low profile to deep-well; from 96- to 1536-well . And when “locked” into place, the microplate varies by as little as +/- 0.1 mm making demanding manipulations a breeze.


Simple status monotoring

All BioShake devices have advanced internal algorithms and sensors for monitoring operating parameters and error detection. Any errors are sending out via RS232 communication interface. Those are easier to detect and localize.

To improve the functional testing during installation and visualizing the operating status all BioShake automation devices are equipped with one integrated LED indication light in front. The indication light allow a quick function test and error control. This have a green and red status that light up either, or are disabled. In case of failure, the error list should read out via RS232 command, to help detect the error more precisely.


Locked & sensor-controlled zero-positioning

In time adjustable stopping operations a defined zero position is automatically extended and locked with an accuracy of 0.1 mm. 

An integrated sensor monitors this zero position and its accuracy. This ensures and simplifies the loading and removal processes and allows accurate pipetting.



For a wide range of applications

The BioShake Q1 comes with a variety of standardized and specific thermo adapter plates. The replacement of the adapters is very simple.

Perfect shaped adapters allow an optimal fit for standard tubes, lysis tubes, microplates, glass vials and other sample vessels. An excellent temperature uniformity and homogeneity is guaranteed for all samples.


Simple intuitive integration in robots and programming

The BioShake can be operated via RS232 or USB user interface. An automatic initialization will start after turn on.

A simple command set allows you to easily control hardware and sensors. The process parameters are constantly controlled and read out. A self-setting zero position of the shaker plate after turning off makes the timeconsuming electrical tracking unnecessary. This ensures a maximum of operating security also in the unmonitored continuous operation.

QInstruments provides approved SILA® drivers for all BioShake units.


First-class finished aluminium housing

Unique and efficient design combined with the most compact housing result in beautiful and well-defined laboratory equipment. Therefore, the first-class finished aluminium housing gives the BioShake Q1 its essential functionality. It provides a high amount of security, device stability and ensures a long service life.

Safety of the user and ease of use are clearly a priority.


High-end instruments for daily routine

A perfectly harmonious blend of high-tech and handmade. "Made in Germany" has always been a recipe for success for QInstruments. 100% of QInstruments production takes place in Germany.

The focus is on human diligence and on being environmentally friendly. The company upholds its quality guarantee by means of consistent quality management. For more than 15 years these lab automation professionals from Jena have used only high-quality materials to ensure sustainable production, applied innovative thinking and undertaken research in a future-oriented way – all as a matter of course.

Recommended mixing speeds

The adjustment of the optimal mixing frequency in depending on filling volume per well should always be made in dependence on the size of the well and the filling volume. 

Only in this way optimum results can be achieved with in shortest process time with a high reproducibility.


Recommended mixing speeds

* Values for 96 - 384  well plates refer to diluted fluids and mixing orbit of 2.0 mm. 
** Values for 1536 well plates refer to mixing orbit of 1.2 mm.


Filling volume in %96 well plates*384 well plates*384 well plates*1536 well plates**
  10 %
1800 - 2200 rpm2200 - 2600 rpm2800 - 3000 rpm4000 - 5000 rpm
  25 %
1600 - 2000 rpm2000 - 2400 rpm2400 - 3000 rpm3500 - 4500 rpm
  50 %
1400 - 1800 rpm1800 - 2200 rpm2200 - 2600 rpm2800 - 3500 rpm 
  75 %
1200 - 1600 rpm1600 - 2000 rpm2000 - 2400 rpm2500 - 3000 rpm



Recommended mixing speeds

All values refer to diluted fluids and mixing orbit of 2.0 mm. 


Filling volume in %0.2 ml tubes0.5 ml tubes1.5 ml tubes2.0 ml tubes
  10-50 %
1400 - 1800 rpm1200 - 1600 rpm1000 - 1300 rpm1000 - 1300 rpm
  50-75 %
1200 - 1500 rpm1100 - 1300 rpm1000 - 1200 rpm900 - 1200 rpm
  75-90 %
1000 - 1300 rpm1000 - 1200 rpm900 - 1100 rpm900 - 1100 rpm



Recommended mixing speeds

All values refer to diluted fluids and mixing orbit of 2.0 mm. 


Filling volume in %0.5 ml vials2.0 ml vials4.0 ml vials6.0 ml vials
  10-50 %
1400 - 1800 rpm1200 - 1600 rpm1000 - 1300 rpm1000 - 1300 rpm
  50-75 %
1200 - 1500 rpm1100 - 1300 rpm1000 - 1200 rpm900 - 1200 rpm
  75-90 %
1000 - 1300 rpm1000 - 1200 rpm900 - 1100 rpm900 - 1100 rpm


For microplates use only

MicroplatesAll microplates according SBS format
48-, 96- up to 384- well microplates, deep well plates, PCR plates
(e.g Eppendorf®Brandt®Nunc®Greiner Bio-One®)

Supported microplate flange heights

2.5 mm, 4.0 mm and 6.1 mm


Mixing frequency200 to 3,000 rpm
Mixing orbitconstant 2.0 mm diameter
(other orbit diameter 1.2 / 3.0 mm on request)
Speed setting resolution1 rpm (linear increments)
Mixing regulation accuracy± 25 rpm
Zero positionLocked zero position, adjustable within 1-4 sec, accuracy ± 0.1 mm
Zero position accuracy± 0.1 mm


Temperature range-20°C to 99°C
up to 24 Kelvin under room temperature (depends on thermo adapter)
Temperature setting0.1°C increment
adjustable from -20°C to 99.9°C
Temperature accuracy± 0.2°C (maximum) from -10°C to +85°C
± 0.25°C (maximum) from -20°C to +100°C

Temperature uniformity

± 1.0 K at 4°C
± 0.5 K at 40°C
± 0.7 K at 75°C
± 1.0 K at 95°C
Cooling/Heating speed above RTca. 16 K/min Heating → 5.0 min from 25°C to 95°C
ca. 12 K/min Cooling → 6.5 min from 95°C to 25°C

(conditions: RT = 21°C, Adapter: 2016-1041, 96-well PCR, adapter temperature)
Cooling/Heating speed below RTca. 12 K/min Heating → 2.2 min from 4°C to 25°C
ca. 4 K/min Cooling → 5.5 min from 25°C to 4°C

(conditions: RT = 21°C, Adapter: 2016-1041, 96-well PCR, adapter temperature)

Plate locking ELM

ELM open modusPlate locking open, ready for free handling with robot gripper
ELM closed modusPlate locking closed, strong diagonal centered fi xation, locked position with accuracy ± 0.1 mm

ELM Position Accuracy

± 0.1 mm

Device control

Electronic control board

Completely accommodated in the smallest housing
Non external controller or components


Micro controller (32-Bit-ARM-Cortex-M4-Prozessor)

Operation control

Remote controlled

User interface

EIA-232 / RS-232 interface (2m cable with RS-232 plug-in connector)
USB via DIGITUS DA-70156 USB-Serial Adapters
USB via MOXA USB-to-Serial Hub
Status & alarmLED in corner area
GREEN = ok  |  RED = alarm  |  BLUE = booting  |  yellow = no communication


Operating Voltages

24 VDC input  .   Imax: 4.5 A  .  Peff: 85 Watt  .  Pmax: 108 Watt

External power supplyExternal power supply unit
(CE/UL/CSA approved, 85-264 VAC, 47-63 Hz, 120W, IEC/EN60320-1 C14)
24 V DC connectionPrewired cable, length 2 m, barrel connector ID 2.5 x OD 5.5 mm
RS-232 interfacePrewired cable, length 2 m, with RS-232 plug-in connector


Housing MaterialAluminum anodized, black
Environment operating range+5°C to 45°C (80 % max. relative humidity)
Dimensions (W x D x H)142 x 99 x 87.5 mm → 5.59 x 3.897 x 3.425 inch (without adapter)
142 x 99 x 97.0 mm → 5.59 x 3.897 x 3.82 inch (top edge of ELM pins)
Weight 1.65 kg (3.637 lbs)



Here we present an overview of available standard adapters, compatible with all automation units:

BioShake 3000 | BioShake 3000-T | BioShake 3000-T elm | BioShake D30-T elm | BioShake Q1 | HeatPlate | ColdPlate



2016-1021 | Microplate . Flat bottom standard
2016-1022 | Microplate . Flat bottom High Base
2016-1032 | Microplate . 96 well round bottom

PCR microplates

2016-1041 | PCR plate . Eppendorf® 96/150µl 
2016-1042 | PCR plate . Bio-Rad® 96/150µl 
2016-1051 | PCR plate . Eppendorf® 384/40µl

Deep well & storage plates

2016-1121 | Deep well . Eppendorf® 96/500-1000 µl
2016-1141 | Deep well . BRAND®/Trefflabs® 96/1.1 ml
2016-1151 | Deep well . NUNC®/Axygen® 96/2.0 ml
2016-1161 | Deep Well . Axygen® 96/0.6 ml
2016-1171| Deep Well . Abgene® 96/2.2 ml
2016-1172 | Deep Well . Abgene®/HJ-Bio®/Greiner® 96/0.8-1.2 ml
2016-1181 | Deep Well . Sarstedt® 96/2.2 ml Megablock
2016-1201 | Deep well  . Corning® 96/320 µl
2016-1214 | Deep well  . Axygen®/Corning®/StarLab® 96/2.0 ml
2016-1215 | 24 well  . Whatman® Uniplate
2016-1217 | Storage plate . NUNC® 96/450 µl
2016-1218 | Deep well . Apricot® 96/2.2 ml

Tubes & Stripes & Vials

Conical shape

2016-1060 | Tubes . 15x 5.0 ml
2016-1061 | Tubes . 24x 2.0 ml . 15x 0.5 ml
2016-1062 | Tubes . 24x 1.5 ml . 15x 0.5 ml
2016-1063 | Tubes . 40x 0.5 ml . 28x 0.2 ml
2016-1064 | PCR Tubes/Stripes/Plates . 96x 0.25 ml
2016-1093 | FALCON® tubes . 5x 50 ml
2016-1094 | FALCON® Tubes . 12x 15 ml

Cylindrical shape

2016-1069 | Vials . 35x 2.0 ml Ø 10.8 mm
2016-1071 | Vials . 35x 2.0 ml Ø 12 mm
2016-1080 | Vials . 35x 2.0 ml Ø 12.5 mm
2016-1078 | Vials . 24x 2.0 ml Ø 12.7 mm
2016-1081 | Vials . 30x 2.0 ml Ø 13 mm
2016-1072 | Vials . 24x 4.0 ml Ø 15 mm
2016-1073 | Vials . 20x 4.0 ml Ø 17 mm
2016-1074 | Vials . 20x 6.0 ml Ø 19 mm

Test software

QCOM 2 is a small test software with a graphical user interface (GUI) to control lab automation instruments from QInstruments, eg. BioShake, ColdPlate, HeatPlate. The main purpose of QCOM 2 is to get easy access to the unit to execute initial testing.

SILA 2 compliant driver

SiLA® is the global initiative to standardize software interfaces in the field of life science research instrumentation. Instigated by the pharmaceutical industry′s need for flexible laboratory automation, the initiative is supported by major device and software suppliers worldwide.

The SiLA® consortium for Standardization in Lab Automation develops and introduces new interface and data management standards allowing rapid integration of lab automation systems. SiLA is a not-for-profit membership corporation with a global footprint and is open to institutions, corporations and individuals active in the life science lab automation industry. Leading system manufacturers, software suppliers, system integrators and Pharma/Biotech corporations have joined the SiLA® consortium and contribute in different technical work groups with their highly skilled experts.

QInstruments provides approved SILA® drivers 1 and 2 for all BioShake units. For development of SILA compliant software we work in close cooperation with Equicon.

To obtain help for installing and running the driver, please contact us.



Nature’s Perfect Design

Leveraging its foundation in innovative automated solutions, QInstruments is a leader in precision mixing & temperature control for sample preparation. QInstruments’s application-specific solutions, small devices, and OEM modules are used in industries ranging from flow cytometry, forensic chemistry to next generation sequencing.

For laboratory automation QInstruments offers extremely robust and smooth orbital shaker, thermoshaker, heater & cooling units. Designed for automation, the black colored premium line defines the global standard for reliable mixing.

With the electronics integrated within the smart modules, there is no need for any other external components. They are completely equipped for hands-free operation with an extensive remote command set for easy software integration.